Enduring nothing short of a debut disaster, Man City's shiny new midfielder Nico Gonzalez was taken off injured in the first half of Saturday's FA Cup win, just after being bundled off the ball before Leyton Orient's freakish opening goal.

Guardiola could not say how severe the Spaniard's issue was immediately after the game, but he now joins Oscar Bobb (leg), Nathan Ake (muscle), Jeremy Doku (unspecified) and Ederson (unspecified) on the doubtful list, while Rodri (ACL) remains sidelined for the long-term.

Likely to be reinstated to the starting XI after scoring the winner on Saturday, Kevin De Bruyne is chasing a slice of Champions League history; the Belgium international's next goal or assist against Real Madrid will be his ninth in the competition, more than any other player.

Meanwhile, Los Blancos head to Manchester in the midst of a defensive crisis, as Lucas Vazquez has suffered a new hamstring injury and joins Antonio Rudiger (thigh), Dani Carvajal (knee), Eder Militao (knee) and David Alaba (muscle) remain sidelined.

A handful of Blancos players are also walking a suspension tightrope, as Jude Bellingham, Luka Modric, Eduardo Camavinga, Endrick and Aurelien Tchouameni will all miss the second leg if they are booked at the Etihad, as will Ancelotti himself.

However, the Italian will not take such concerns into consideration as he puts out his most powerful XI at the Etihad, where Tchouameni will once again be forced into an emergency centre-back role with the up-and-coming Raul Asencio.